Although low profile tubes were introduced in the marketplace back in 2000, some companies have renamed the original low profile 0.2 ml vessels description to 0.1 ml “vessel”. Low profile (0.1 ml) products are used in “fast cyclers” from ABI, Roche LightCycler ® 480 systems as well in (q)PCR cyclers with height adjustable lids. The difference between low profile 0.1 ml vessels and regular products is the height of the product and consequently the volume it can hold. More than half of a regular-profile strip remains above the thermal block level. In low profile tubes there is a smaller “air” volume above the reaction mix than in regular and high profile tubes. This allows less reaction mix to go into gas phase, leading to less concentration of the samples, less change in reaction conditions and therefore to more reproducible results. Most fast cyclers accept low profile tubes, strips and plates. Most regular PCR cyclers accept regular profile and high profile file products. (tubes, tube-strips and plates). Thermal cyclers without height-adjustable heated lids accept only one type, mainly regular height products. BIOplastics products are available in all profile versions. The differences between low profile (0.1ml), regular profile and high profile products are illustrated in the drawing and photographs below.